Mt Everest trek causes impaired cardiac high energy phosphate metabolism and diastolic impairment
نویسندگان
چکیده
منابع مشابه
Altered Cardiac High-Energy Phosphate Metabolism in Heart Failure
Background. The purpose of this work was to further define the value of cardiac 3'P magnetic resonance (MR) spectroscopy for patients with coronary artery disease and dilated cardiomyopathy. Methods and Results. Blood-corrected and Tl-corrected 3`P MR spectra of anteroseptal myocardium were obtained at rest using image-selected in vivo spectroscopy localization, a selected volume of 85± 12 cm3,...
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The effects of phosphate depletion (PD) of 4, 8, and 12 weeks on skeletal muscle energy metabolism were studied in rats fed a phosphate deficiency diet and compared with rats pairfed with a normal phosphate diet. Skeletal muscle biopsy specimens were examined for energy production, transport, and utilization. The results show that already by 4 weeks of PD, the concentration of inorganic phospho...
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Hypoxia-inducible factor (HIF) appears to function as a global master regulator of cellular and systemic responses to hypoxia. HIF pathway manipulation is of therapeutic interest; however, global systemic upregulation of HIF may have as yet unknown effects on multiple processes. We used a mouse model of Chuvash polycythemia (CP), a rare genetic disorder that modestly increases expression of HIF...
متن کاملEnergy metabolism increases and regional body fat decreases while regional muscle mass is spared in humans climbing Mt. Everest.
The objectives of the study were to determine regional changes in body composition, energy expenditure by means of doubly labeled water, and net energy balance during exposure to high and extreme altitudes (5,300-8,848 m). This study focuses on a subset of subjects who consumed the doubly labeled water (three base camp personnel and seven climbers). Regional body composition was determined by m...
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ژورنال
عنوان ژورنال: Journal of Cardiovascular Magnetic Resonance
سال: 2009
ISSN: 1532-429X
DOI: 10.1186/1532-429x-11-s1-o6